Atp-binding cassette protein

Details Atp-binding cassette protein Atp-binding cassette protein

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C12N 5/10 (2006.01) C12N 15/11 (2006.01) C12N 15/85 (2006.01) C12P 21/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2422508

The invention provides a mammalian cDNA which encodes a mammalian ATP-binding cassette protein. It also provides for the use of the cDNA, fragments, complements, and variants thereof and of the encoded protein, portions thereof and antibodies thereto for diagnosis and treatment of breast disorders, particularly breast proliferative fibrocystic disease, breast adenocarcinoma, and drug resistance. The invention additionally provides expression vectors and host cells for the production of the protein and a transgenic model system.

L'invention concerne un ADNc de mammifère qui code une protéine de mammifère de cassette de liaison à l'ATP. Elle concerne également l'utilisation dudit ADNc, des fragments, des compléments et des variants de celui-ci, et de la protéine codée, de parties de celle-ci et d'anticorps dirigés contre celle-ci pour le diagnostic et le traitement de mastopathies, en particulier de la fibrose kystique proliférative du sein, de l'adénocarcinome du sein et de la résistance aux médicaments. L'invention concerne en outre des vecteurs d'expression et des cellules hôtes pour la production de cette protéine et d'un système modèle transgénique.

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