Atp-binding cassette transporter (abc1) modified transgenic...

Details Atp-binding cassette transporter (abc1) modified transgenic... Atp-binding cassette transporter (abc1) modified transgenic...

A - Human Necessities

01

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A01K 67/00 (2006.01) A01K 67/027 (2006.01) C07K 14/705 (2006.01) C12N 5/00 (2006.01) C12N 5/10 (2006.01) C12N 15/00 (2006.01) C12N 15/85 (2006.01)

Patent

CA 2385154

A transgenic mouse with alterations in an abc1 gene is prepared by introduction of an altered abc1 gene into a host animal. The resulting transgenic mice do not produce functional ABC1 protein molecules. Cells and cell lines derived from these animals also contain the altered abc1 gene.

On prépare une souris transgénique comportant des modifications dans un gène abc1 en introduisant un gène modifié abc1 chez un animal hôte. Les souris transgéniques résultantes ne produisent pas de molécules de protéines ABC1 fonctionnelles. Des cellules et des lignées cellulaires dérivées de ces animaux contiennent également le gène abc1 modifié.

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