Atp-sensitive potassium channel gene-defective animals

Details Atp-sensitive potassium channel gene-defective animals Atp-sensitive potassium channel gene-defective animals

C - Chemistry, Metallurgy

12

N

C12N 5/10 (2006.01) A01K 67/027 (2006.01) C07K 14/705 (2006.01) C12N 15/85 (2006.01)

Patent

CA 2254178

19 A Kir6.2 gene-defective, non-human mammal, a mouse in particular, its tissues and cells are provided, wherein the ATP-sensitive potassium channel Kir6.2 gene, one of the subunits of KATP channels essential for insulin secretion by pancreatic .beta.-cells, is lost from one or both of the allelic loci.

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