Atrial hypotensive peptide having 46 amino acids

Details Atrial hypotensive peptide having 46 amino acids Atrial hypotensive peptide having 46 amino acids

C - Chemistry, Metallurgy

07

K

167/40, 530/7.1,

C07K 14/58 (2006.01) A61K 38/22 (2006.01) G01N 33/53 (2006.01) G01N 33/74 (2006.01)

Patent

CA 1339388

An atrial natriuretic peptide having profound natriuretic, diuretic and hypotensive effects, characterized by a 46 amino acid residue sequence: Ser-Gln-Asp-Ser-Ala-Phe-Arg-Ile-Gln-Glu-Arg-Leu-Arg- Asn-Ser-Lys-Met-Ala-His-Ser-Ser-Ser-Cys-Phe-Gly-Gln- Lys-Ile-Asp-Arg-Ile-Gly-Ala-Val-Ser-Arg-Leu-Gly-Cys- Asp-Ile-Leu-Leu-Ile-Ala-Gln, having a disulphide bond between the cysteine residues which may be extracted from mammalian heart atria is described. A synthetic 30 amino acid residue peptide corresponding to residues 17-46 of the above sequence has also been prepared and shown to have similar biological activity.

570432

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