Atrial natriuretic peptide derivative, its production and...

Details Atrial natriuretic peptide derivative, its production and... Atrial natriuretic peptide derivative, its production and...

C - Chemistry, Metallurgy

07

K

530/7.1

C07K 14/58 (2006.01) A61K 38/22 (2006.01) C07K 14/60 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1339678

A peptide derivative of the formula (see fig. I) wherein A is hydrogen or a hydrocarbon acyl having 2 to 18 carbon atoms which is substituted by an amino group at the .alpha.-position; B is F-Gly wherein F is a neutral .alpha.-amino acid residue, or NH-(CH2)nCO wherein n is an integer of 1 to 4; C is a neutral .alpha.-amino acid residue; and E is L-Arg or D-Arg; when A, B and C are hydrogen, Gly-Gly, and Met or Ile, respectively, E is D-Arg, or its pharmacologically acceptable salt has strong hypotensive and natriuretic activity; therefore it is useful as a therapeutic drug for hypertension, a diuretic, and a therapeutic drug for cardiac and cerebral circulatory diseases.

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