Atrial peptide having useful natriuretic, diuretic and...

Details Atrial peptide having useful natriuretic, diuretic and... Atrial peptide having useful natriuretic, diuretic and...

C - Chemistry, Metallurgy

07

K

530/13, 167/205

C07K 14/58 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1244407

Abstract of the Disclosure A novel atrial peptide having useful natriuretic, diuretic and vasodilating activity is disclosed with the following amino acid sequence: Lys-Asn-Leu-Leu-Asp-His-Leu-Glu-Glu-Lys-Met-Pro-Vaal-Glu-Asp- Glu-Val-Met-Pro-Pro-Gln-Ala-Leu-Ser-Glu-Gln-Thr-Assp-Glu-Ala- Gly-Ala-Ala-Leu-Ser-Ser-Leu-Ser-Glu-Val-Pro-Pro-Trp-Thr-Gly- Glu-Val-Asn-Pro-Ser-Gln-Arg-Asp-Gly-Gly-Ala-Leu-Glly-Arg-Gly- Pro-Trp-Asp-Pro-Ser-Asp-Arg-Ser-Ala-Leu-Leu-Lys-Seer-Lys-Leu- Arg-Ala-Leu-Leu-Ala-Gly-Pro-Arg-Ser-Leu-Arg-Arg-Ser-Ser-C?s- 100 105 Phe-Gly-Gly-Arg-Ile-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly- 110 C?s-Asn-Ser-Phe-Arg-Tyr-COOH

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