Atrichia mouse

Details Atrichia mouse Atrichia mouse

A - Human Necessities

01

K

A01K 67/027 (2006.01) C12Q 1/00 (2006.01)

Patent

CA 2262375

The invention relates to an atrichia mouse which grows juvenile hair but is deficient in the ability to grow pelage hair and, more particularly, to an atrichia mouse such that the spontaneous prevalence of wet and dry skin lesions is not less than 70% at the 24th week of age, the number of mast cells in the skin is not less than about 50/linear mm at the 24th week of age, and the serum IgE level is not less than about 3500 ng/ml at the 24th week of age. The atrichia mouse of the invention finds application as an animal model of disease for the research and development of therapeutic drugs for dermatitis, among other kinds of drugs.

Cette invention concerne une souris nue sur laquelle peut pousser une fourrure juvénile mais pas de fourrure adulte. Cette invention concerne plus précisément une souris nue qui possède un rapport d'attaque spontanée de lésions sèches et humides de la peau d'au moins 70 % à l'âge de 24 semaines ou plus, un nombre de mastocytes sur la peau d'environ 50/mm ou plus à l'âge de 24 semaines et, enfin, une valeur d'anticorps IgE sanguins d'environ 3500 ng/ml ou plus à l'âge de 24 semaines. Cette souris peut être utilisée en qualité d'animal de type modèle pour maladies dans la recherche et le développement de remèdes contre les dermatites.

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