Atropisomers of 3-aryl-4(3h)-quinazolinones and their use as...

Details Atropisomers of 3-aryl-4(3h)-quinazolinones and their use as... Atropisomers of 3-aryl-4(3h)-quinazolinones and their use as...

C - Chemistry, Metallurgy

07

D

C07D 239/91 (2006.01) A61K 31/505 (2006.01) C07D 401/06 (2006.01) C07D 401/14 (2006.01) C07D 405/06 (2006.01) C07D 413/06 (2006.01) C07D 417/06 (2006.01)

Patent

CA 2282277

Atropisomers of formula (Ia), wherein R2 is an optionally substituted aryl or heteroaryl, R5 is alkyl, halo, CF3, alkoxy or alkylthio, R6, R7 and R8 are hydrogen or halo, and R3 is hydrogen, halo, CN, NO2, CF3, alkyl or alkoxy, are useful as AMPA receptor antagonists, particularly in the treatment of neurodegenerative and CNS-trauma related conditions.

Atropisomères de formule (Ia), dans laquelle R<2> est aryle ou hétéroaryle éventuellement substitué, R<5> est alkyle, halo, CF3, alcoxy ou alkylthio, R<6>, R<7> et R<8> sont hydrogène ou halo, et R<3> est hydrogène, halo, CN, NO2, CF3, alkyle ou alcoxy. Ces composés sont utiles comme antagonistes des récepteurs de l'AMPA, notamment pour le traitement des troubles neurodégénératifs et des troubles liés à un traumatisme du système nerveux central.

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