Atropisomers of (hydroxyalkyl) pyrrole derivatives

Details Atropisomers of (hydroxyalkyl) pyrrole derivatives Atropisomers of (hydroxyalkyl) pyrrole derivatives

C - Chemistry, Metallurgy

07

D

C07D 207/34 (2006.01) A61K 31/40 (2006.01) A61P 9/00 (2006.01)

Patent

CA 2736923

The present invention comprises a compound for the prevention and/or treatment of cardiovascular diseases. The compound is an atropisomer of a compound represented by the following general formula (I ) : wherein R1 represents a C1-C3 alkyl group; R2 represents a 2-hydroxy- C4-C6 alkyl group; R3 represents a halogeno group, a halogeno-C1-C3 alkyl group and the like; R4 represents a hydrogen atom, a halogeno group and the like; R5 represents a C1-C3 alkyl group; and R6 represents a hydrogen atom, a halogeno group and the like] or atropisomers thereof.

La présente invention concerne un composé destiné au traitement prophylactique et/ou thérapeutique de maladies cardio-vasculaires. Le composé est un atropoisomère d'un composé de formule générale (I) suivante : où R1 représente un groupement alkyle en C1-C3 ; R2 représente un groupement 2-hydroxy-alkyle en C4-C6 ; R3 représente un groupement halogéno, un groupement halogénoalkyle en C1-C3, etc. ; R4 représente un atome d'hydrogène, un groupement halogéno, etc. ; R5 représente un groupement alkyle en C1-C3 ; et R6 représente un atome d'hydrogène, un groupement halogéno, etc., ou ses atropoisomères.

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