Attaching substances to micro-organisms

Details Attaching substances to micro-organisms Attaching substances to micro-organisms

C - Chemistry, Metallurgy

12

N

C12N 15/31 (2006.01) A23L 1/03 (2006.01) A61K 38/02 (2006.01) B01J 20/00 (2006.01) C07K 14/195 (2006.01) C07K 14/315 (2006.01) C07K 14/37 (2006.01) C12N 1/20 (2006.01) C12N 9/36 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2310228

The invention relates to surface display of proteins on micro-organisms via the targeting and anchoring of heterologous proteins to the outer surface of cells such as yeast, fungi, mammalian and plant cells, and bacteria. The invention provides a proteinaceous substance comprising a reactive group and at least one attaching peptide which comprises a stretch of amino acids having a sequence corresponding to at least a part of the consensus amino acid sequence listed in figure 10 and comprises a method for attaching a proteinaceous substance to the cell wall of a micro-organism comprising the use of said attaching peptide.

Cette invention a trait à une technique permettant de faire apparaître des protéines à la surface de micro-organismes par ciblage de protéines hétérologues et ancrage de celles-ci à la surface extérieure de cellules, notamment des levures, des cellules de champignons, de végétaux et de mammifères, ainsi qu'à la surface extérieure de bactéries. Elle concerne également une substance protéinique possédant un groupe réactif et au moins un peptide de fixation qui comporte une extension d'acides aminés possédant une séquence correspondant à au moins une partie de la séquence consensus aminoacide représentée dans la figure 10. L'invention porte, de surcroît, sur une technique permettant de fixer une substance protéinique à la paroi cellulaire d'un micro-organisme en faisant intervenir ledit peptide de fixation.

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