Attachment of cells to surfaces

Details Attachment of cells to surfaces Attachment of cells to surfaces

C - Chemistry, Metallurgy

07

K

C07K 17/00 (2006.01) C07C 29/00 (2006.01) C12N 5/00 (2006.01)

Patent

CA 2534576

The present invention relates to a microcarrier onto the surface of which a cationic compound has been immobilised via a guanidine group. The microcarrier is capable of attachment of cells, e.g. via charge-based interaction, and is advantageously used as a support in the culture of cells. Said compound may comprise one or two amino acids, such as arginine (Arg) or a dipeptide. The invention also relates to a method of preparing a polycationic microcarrier, which method comprises to immobilise a compound that comprises at least one guanidine group to an epoxide-activated substrate.

La présente invention concerne un microsupport à la surface duquel un composé cationique a été immobilisé via un groupe de guanidine. Le microsupport est capable d'assurer la fixation de cellules, par exemple, par l'interaction basée sur les charges, et peut s'utiliser avantageusement en tant que support dans la culture de cellules. Ce composé peut comprendre un ou deux acides aminés tels que l'arginine (Arg) ou un dipeptide. L'invention concerne aussi un procédé pour préparer un microsupport polycationique, ledit procédé consistant à immobiliser un composé qui comprend au moins un groupe de guanidine sur un support activé par époxyde.

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