A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/108 (2006.01) C07K 14/245 (2006.01) C12N 15/70 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2460025
The invention provides strains of bacteria, especially enterotoxigenic E. coli, attenuated by mutations in the genes encoding enterotoxins (LT, ST, EAST1) and optionally further attenuated by deletion of additional chromosomal genes. In addition the invention provides strains of attenuated bacteria expressing immunogenic but non-toxic variants of one or more of these enterotoxins. These bacteria are useful as a vaccine against diarrhoeal disease.
L'invention concerne des souches de bactéries, en particulier <i>E. coli</i> entérotoxigène, atténuées par des mutations au niveau de gènes codant des entérotoxines (LT, ST, EAST1) et éventuellement également atténuées par la suppression de gènes chromosomaux complémentaires. En outre, l'invention concerne des souches de bactéries atténuées exprimant des variants immunogéniques mais non toxiques d'une ou de plusieurs de ces entérotoxines. Ces bactéries sont utiles en tant que vaccins contre des maladies diarrhéiques.
Beavis Juliet Claire
Darsley Michael James
Greenwood Judith
Stephens Jonathan Clive
Turner Arthur Keith
Acambis Research Limited
Macrae & Co.
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