C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 1/21 (2006.01) A61K 39/02 (2006.01) A61K 39/112 (2006.01) A61K 39/12 (2006.01) A61P 31/00 (2006.01) A61P 35/00 (2006.01) C07K 14/005 (2006.01) C07K 14/195 (2006.01) C07K 14/255 (2006.01) C07K 14/47 (2006.01) C07K 16/12 (2006.01) C12N 1/36 (2006.01) A61K 39/00 (2006.01) C12N 15/31 (2006.01) C12N 15/37 (2006.01) C12N 15/38 (2006.01) C12N 15/51 (2006.01) C12N 15/62 (2006.01) C12N 15/63 (2006.01) C12N 15/74 (2006.01)
Patent
CA 2341349
The present invention relates to vaccines, in particular, to an attenuated gram-negative cell comprising the SPI2 gene locus, wherein at least one gene of the SPI2 locus is inactivated, wherein said inactivation results in an attenuation/reduction of virulence compared to the wild type of said cell, and to a carrier for the presentation of an antigen to a host, which carrier is said attenuated gram-negative cell, wherein said cell comprises at least one heterologous nucleic acid molecule comprising a nucleic acid sequence coding for said antigen, wherein said cell is capable of expressing said nucleic acid molecule or capable of causing the expression of said nucleic acid molecule in a target cell.
L'invention porte sur des vaccins et en particulier sur des cellules gram-négatives comprenant le locus de gènes du SPI2, l'un au moins des gènes du locus du SPI2 étant inactivé, ladite inactivation se traduisant par une atténuation/réduction de la virulence par comparaison au type sauvage de ladite cellule. L'invention porte également sur un porteur de présentation d'un antigène à un hôte constitué par ladite cellule gram-négative atténuée. Cette dernière comporte au moins une séquence d'acide nucléique codant pour ledit antigène et capable d'exprimer ladite molécule d'acide nucléique et d'en causer l'expression dans une cellule cible.
Apfel Heiko
Guzman Carlos Alberto
Hensel Michael
Holden David
Hueck Christoph
Creatogen Aktiengesellschaft
Emergent Product Development Uk Limited
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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