Attenuated dengue-4 virus vaccine

Details Attenuated dengue-4 virus vaccine Attenuated dengue-4 virus vaccine

A - Human Necessities

61

K

A61K 39/12 (2006.01) A61P 31/14 (2006.01) C07K 14/18 (2006.01) C12N 7/08 (2006.01) C12N 15/40 (2006.01)

Patent

CA 2368673

The present invention provides vaccine compositions of attenuated dengue-4 virus. More specifically, the attenuated virus is produced by serial passage in PDK cells. The invention also provides methods for stimulating the immune system of an individual to induce protection against dengue-4 virus by administration of attenuated dengue-4 virus.

Cette invention concerne des compositions de vaccin contre le virus-4 att~nu~ de la dengue. Plus pr~cis~ment, le virus att~nu~ s'obtient par passage s~riel dans des cultures primaires de cellules r~nales de chien. Cette invention concerne ~galement des m~thodes permettant de stimuler le syst­me immunitaire d'un individu dans le but d'induire une protection contre le virus-4 de la dengue gr~ce ~ l'administration d'un virus-4 att~nu~.

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