C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/41 (2006.01) A61K 39/125 (2006.01) A61K 39/13 (2006.01) C12N 7/04 (2006.01) C12N 15/00 (2006.01)
Patent
CA 2045649
An attenuated enterovirus or rhinovirus, suitable for use as a vaccine, has a reversed base pairing in the part, or in a part corresponding to the part,of the 5' non-coding region of the genome of poliovirus type 3 Leon strain shown below: 471 477 483 ... U C C .. C C A U G G A ... A G G .. G G U G C C U 538 534 528 A suitable attenuated poliovirus has the bases G and C at positions 469 and 534 respectively for a type 1 or type 2 poliovirus or at posts 472 and 537 respectively for a type 3 poliovirus.
Un entérovirus ou un rhinovirus atténué, pouvant être utilisé comme un vaccin, présente une paire de bases inversées dans la partie, ou dans une partie correspondant à la partie, de la région non codante en 5' du génome de la souche Leon du poliovirus de type 3 illustrée ci-après : 471 477 483 ...UCC...CCAUGGA ... AGG .. GGUGCCU 538 534 528. Un poliovirus atténué convenable a les bases G et C aux positions 469 et 534 respectivement pour un poliovirus de type 1 ou de type 2 ou aux positions 472 et 537 respectivement pour un poliovirus de type 3.
Almond Jeffrey W.
Minor Philip D.
Skinner Michael A.
Young Colin R.
British Technology Group Limited
Mccarthy Tetrault Llp
National Research Development Corporation
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