Attenuated flaviviral live vaccine comprising a capsid...

Details Attenuated flaviviral live vaccine comprising a capsid... Attenuated flaviviral live vaccine comprising a capsid...

C - Chemistry, Metallurgy

12

N

C12N 7/04 (2006.01) A61K 39/00 (2006.01) C07K 14/18 (2006.01) C12N 15/40 (2006.01)

Patent

CA 2432370

An attenuated flaviviral live vaccine is disclosed, comprising a flaviviral mutant, characterised in that the flaviviral mutant comprises a capsid protein deletion of at least more than 4 sequential amino acids, whereby the hydrophobic carboxy-terminal region is not affected by said deletion.

L'invention concerne un vaccin atténué à flavivirus vivant, renfermant un flavivirus mutant et caractérisé en ce que ce flavivirus mutant présente une délétion dans la protéine capsidique d'au moins plus de 4 acides aminés successifs, la région hydrophobe carboxy-terminale n'étant pas concernée par cette délétion.

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