Attenuated forms of bovine viral diarrhea virus

Details Attenuated forms of bovine viral diarrhea virus Attenuated forms of bovine viral diarrhea virus

C - Chemistry, Metallurgy

12

N

C12N 7/04 (2006.01) A61K 39/12 (2006.01) C07K 16/08 (2006.01) C12N 5/10 (2006.01) C12N 15/33 (2006.01) G01N 33/569 (2006.01)

Patent

CA 2363493

The present invention relates to attenuated forms of bovine viral diarrhea (BVD) viruses. In particular, the present invention relates to attenuated BVD viruses made by mutating the N pro protease gene and inserting a bovine ubiquitin coding sequence. The attenuated viruses of the present invention can be used to raise antibodies against BVDV. Immunogenic compositions and vaccine compositions, as wail as therapeutic and diagnosis methods, are also provided by the present invention.

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