Attenuated francisella and methods of use

Details Attenuated francisella and methods of use Attenuated francisella and methods of use

C - Chemistry, Metallurgy

12

N

C12N 1/20 (2006.01) A01N 63/00 (2006.01) A61K 39/02 (2006.01) A61P 31/04 (2006.01) A61P 37/04 (2006.01) C12N 1/21 (2006.01) C12N 15/00 (2006.01) A61K 35/74 (2006.01)

Patent

CA 2643791

Francisella tularensis is the bacterial pathogen that causes tularemia in humans and a number of animals. To date, no approved vaccine exists for this widespread and life- threatening disease. The present disclosure provides attenuated Francisella mutants that include functional deletions in one or more of the dsbB, FTT0742, pdpB,fumA, and carB genes. Also provided are immunogenic compositions that include the attenuated bacteria. Methods are provided for treatment using the attenuated Francisella mutants.

Francisella tularensis est l'agent pathogène bactérien responsable de la tularémie chez l'homme et chez un certain nombre d'animaux. À ce jour, aucun vaccin approuvé contre cette maladie mortelle largement répandue n'existe. La présente invention concerne des mutants atténués de Francisella qui incluent des délétions fonctionnelles dans un ou plusieurs des gènes dsbB, FTT0742, pdpB, fumA et carB. La présente invention concerne également des compositions immunogènes qui incluent les bactéries atténuées. La présente invention concerne également les méthodes de traitement utilisant les mutants de Francisella atténués.

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