Attenuated gram negative bacteria

Details Attenuated gram negative bacteria Attenuated gram negative bacteria

C - Chemistry, Metallurgy

12

N

C12N 15/31 (2006.01) A61K 38/16 (2006.01) A61K 39/102 (2006.01) C07K 14/285 (2006.01) C07K 16/12 (2006.01) C12N 1/21 (2006.01) C12Q 1/68 (2006.01) G01N 33/569 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2481186

Disclosed and claimed are a mutant of a gram negative bacterium, wherein said bacterium has at least one mutation in a nucleotide sequence which codes for a polypeptide having an identity which is equal or more than 70 %, 75 % , 80 %, 85 %, 90 %, 95 %, 96 % , 97 %, 98 %, or 99 % with an amino acid sequence coded by a nucleotide sequence selected from the group consisting of nucleotide sequences identifies SEQ ID NO: 2, 6, 9, 12, 16, 19, 22, 25, 28, 31, 34, 37, 40, 43, 46, 49, 52, 55, 58, 61, 64, 67, 70, 75, 78, 81, 84, 87, 90, 93; said mutation resulting in attenuated virulence of the bacterium. Immunogenic compositions and vaccines containing such as a mutant are also disclosed and claimed.

L'invention concerne un mutant d'une bactérie gram négative, cette bactérie possédant au moins une mutation dans une séquence nucléotidique codant un polypeptide d'une identité supérieure ou égale à 70 %, 75 %, 80 %, 85 %, 90 %, 95 %, 96 %, 97 %, 98 %, ou 99 % avec une séquence d'acides aminés codée par une séquence nucléotidique choisie dans le groupe comprenant les séquences nucléotidiques appelées SEQ ID NO: 2, 6, 9, 12, 16, 19, 22, 25, 28, 31, 34, 37, 40, 43, 46, 49, 52, 55, 58, 61, 64, 67, 70, 75, 78, 81, 84, 87, 90, 93. Cette mutation a pour résultat une virulence atténuée de la bactérie. L'invention concerne également des compositions immunogènes ainsi que des vaccins contenant un tel mutant.

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