C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 7/00 (2006.01)
Patent
CA 2605878
The invention provides self replicating infectious recombinant paramyxoviruses. The recombinant paramyxovirus preferably have one or more attenuating mutations. In some embodiments, the recombinant paramyxovirus has a separate variant polynucleotide encoding a P protein and a separate monocistronic polynucleotide encoding a V protein. In some embodiments, recombinant paramyxovirus have at least one temperature sensitive mutation and one non-temperature sensitive mutation. Also provided are compositions and methods for using the recombinant paramyxoviruses as described herein.
L'invention concerne des paramyxovirus recombinants infectieux à autoréplication. Le paramyxovirus recombinant a de préférence une ou plusieurs mutations d'atténuation. Dans certains modes de réalisation, le paramyxovirus recombinant a un polynucléotide variant séparé codant une protéine P et un polynucléotide monocistronique séparé codant une protéine V. Dans d'autres modes de réalisation, le paramyxovirus recombinant présente au moins une mutation thermosensible et une mutation non thermosensible. L'invention porte également sur des compositions et des procédés d'utilisation de ces paramyxovirus recombinants.
Collins Peter L.
Murphy Brian R.
Nolan Sheila
Skiadopoulos Mario H.
Department Of Health And Human Services The Government Of The United States Of America Represented By Th
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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