Attenuated influenza virus useful as vaccine

Details Attenuated influenza virus useful as vaccine Attenuated influenza virus useful as vaccine

C - Chemistry, Metallurgy

12

N

C12N 7/04 (2006.01) A61K 35/76 (2006.01) A61K 39/145 (2006.01) A61K 39/295 (2006.01) A61K 48/00 (2006.01) C12N 5/10 (2006.01) C12N 7/01 (2006.01) C12N 15/86 (2006.01)

Patent

CA 2380514

A negative-sense single stranded RNA virus attenuated by replacement of the poly U track in a genomic nucleic acid by a poly A track which is capable of being copied to provide a poly U tail for mRNA transcribed from the nucleic acid. The virus is typically influenza virus. The virus may be incorporated into a vaccine or used as a helper virus.

L'invention porte sur un virus à ARN monobrin antisens, atténué par remplacement de la piste poly U de l'acide nucléique d'un génome par une piste poly A, et pouvant être copié pour fournir une queue poly U à l'ARNm transcrit à partir de l'acide nucléique. Ledit virus, typique de la grippe, peut être incorporé à un vaccin ou servir de virus assistant.

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