Attenuated listeria spp. and methods for using the same

Details Attenuated listeria spp. and methods for using the same Attenuated listeria spp. and methods for using the same

C - Chemistry, Metallurgy

12

N

C12N 1/20 (2006.01)

Patent

CA 2486980

Attenuated Listeria bacteria are provided. The subject bacteria are characterized by having a mutation in a gene chosen from the lplA gene and the hly gene. The subject bacteria find use in a variety of applications, where representative applications of interest include, but are not limited to: (a) use of the subject bacteria as adjuvants; (b) use of the subject bacteria as delivery vectors for introducing macromolecules into a cell; (c) use of the subject bacteria as vaccines for eliciting or boosting a cellular immune response; etc.

L'invention concerne des bactéries Listeria atténuées, qui se caractérisent en ce qu'elles présentent une mutation dans un gène choisi entre le gène lplA et le gène hly. Les bactéries de l'invention peuvent intervenir dans diverses applications, dont des applications représentatives incluant, mais pas exclusivement, l'utilisation des bactéries comme: a) adjuvants; b) vecteurs d'administration servant à introduire des macromolécules dans une cellule; c) vaccins destinés à éliciter ou amplifier une réponse immunitaire cellulaire, etc.

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