Attenuated minus-stranded rna virus

Details Attenuated minus-stranded rna virus Attenuated minus-stranded rna virus

C - Chemistry, Metallurgy

12

N

C12N 15/09 (2006.01) C12N 7/00 (2006.01) C07K 14/08 (2006.01) C07K 14/115 (2006.01)

Patent

CA 2677659

Disclosed is attenuated minus-stranded RNA virus. It is found that the mutation of an amino acid residue at position-1214 in the amino acid sequence for Sendai virus L-protein (Y1214F) can inhibit the genome replication activity and/or the genome transcription activity of the virus. It is also found that a cytotoxicity or immunological response can be reduced compared with the original one by deleting a specific gene from a viral genome.

L'invention concerne un virus à ARN à brin négatif atténué. Il a été trouvé que la mutation d'un résidu d'acide aminé au niveau de la position 1214 dans la séquence d'acides aminés de la protéine L du virus Sendai (Y1214F) pouvait inhiber l'activité de réplication du génome et/ou l'activité de transcription du génome du virus. Il a également été trouvé que la cytotoxicité ou la réponse immunologique pouvait être réduite par rapport au virus d'origine en supprimant un gène particulier d'un génome viral.

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