Attenuated polioviruses

Details Attenuated polioviruses Attenuated polioviruses

A - Human Necessities

61

K

A61K 39/13 (2006.01) C12N 7/04 (2006.01)

Patent

CA 2660375

The invention provides an attenuated poliovirus which does not have a base pair mismatch in stem (a) or (b) of domain V of the 5' non-coding region of its genome, wherein at least seven of the base pairs in stems (a) and (b) are U-A or A-U base pairs.

La présente invention concerne un poliovirus atténué qui ne comporte pas de mésappariement de bases dans la branche (a) ou (b) du domaine V de la région 5' non codante de son génome, au moins sept des paires de base dans les branches (a) et (b) étant des paires de base U-A ou A-U.

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