Attenuated polioviruses

Details Attenuated polioviruses Attenuated polioviruses

C - Chemistry, Metallurgy

12

N

C12N 7/04 (2006.01) A61K 39/13 (2006.01)

Patent

CA 2283638

An attenuated poliovirus, suitable for vaccination against poliomyelitis, does not have a U-G base pair or other base pair mismatch in stem (a) or (b) of domain V of the 5' non-coding region of the poliovirus genome. The attenuated poliovirus may be a type 3 poliovirus whose 5' non-coding region contains the following U-A base pairs: (a) U-A at positions 472-537, U-A at positions 478- 533 and U-A at positions 480-531; (b) U-A at positions 472-537, U-A at positions 480-531 and U-A at positions 481-530; or (c) U-A at positions 472- 537, U-A at positions 480-531 and A-U at positions 482-529.

L'invention se rapporte à un poliovirus atténué approprié à la vaccination contre la poliomyélite. Ledit virus ne présente pas de paire de bases U-G ou d'autres mauvais appariements de paire de bases dans la souche (a) ou (b) du domaine V de la région non codante 5' du génome du poliovirus. Le poliovirus atténué peut être un poliovirus de type 3 dont la région non codante 5' contient les paires de bases U-A suivantes: (a) U-A aux emplacements 472-537, U-A aux emplacements 478-533 et U-A aux emplacements 480-531; (b) U-A aux emplacements 472-537, U-A aux emplacements 480-531 et U-A aux emplacements 481-530; ou (c) U-A aux emplacements 472-537, U-A aux emplacements 480-531 et A-U aux emplacements 482-529.

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