A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/155 (2006.01) C12N 7/01 (2006.01) C12N 7/04 (2006.01)
Patent
CA 2118509
The present invention provides vaccine compositions of attenuated respiratory syncytial virus (RSV). More particularly, the attenuated virus may be a derivative of RSV which has been incompletely attenuated by cold-passage or introduction of muta-tions which produce virus having a temperature sensitive (ts) or cold adapted (ca) phenotype. The invention also provides meth-ods for stimulating the immune system of an individual to induce protection against respiratory syncytial virus by administration of attenuated RSV. The invention also provides pure cultures of attenuated RS virus, wherein the virus has been more completely attenuated by the further derivatization of previously identified incompletely attenuated ts or cp mutants.
Chanock Robert M.
Connors Mark
Crowe James E. Jr.
Davis Alan R.
Hsu Kuo-Hom L.
American Home Products Corporation
Department O. F. Health And Human Services The United States Of America Represented By The Secretary
Ridout & Maybee Llp
The United States Of America As Represented By The Department Of Health And Human Services
Wyeth
LandOfFree
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