Attenuated respiratory syncytial viruses

Details Attenuated respiratory syncytial viruses Attenuated respiratory syncytial viruses

C - Chemistry, Metallurgy

12

N

C12N 15/45 (2006.01) A61K 39/155 (2006.01) C07K 14/135 (2006.01) C12N 7/08 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2302867

Isolated, recombinantly-generated, attenuated, respiratory syncytial viruses of subgroup B having at least one attenuating mutation in the RNA polymerase gene are described. Vaccines are formulated comprising such viruses and a physiologically acceptable carrier. The vaccines are used for immunizing an individual to induce protection against respiratory syncytial virus.

Virus syncytiaux respiratoires atténués, isolés, générés par recombinaison, appartenant au sous-groupe B et possédant au moins une mutation d'atténuation dans le gène de polymérase d'ARN. Formulations de vaccins comprenant ces virus, ainsi qu'un véhicule acceptable sur le plan physiologique. On utilise ces vaccins dans le but d'immuniser un individu afin d'induire une protection contre le virus syncytial respiratoire.

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