Attenuated strains of flaviviruses , and uses thereof

Details Attenuated strains of flaviviruses , and uses thereof Attenuated strains of flaviviruses , and uses thereof

A - Human Necessities

61

K

A61K 39/12 (2006.01) C07K 14/18 (2006.01)

Patent

CA 2616026

Methods and compositions concerning mutant flaviviruses with reduced virulence. In some embodiments the invention concerns nucleotide sequences that encode mutant flaviviral proteins. Viruses comprising mutant NSl and NS4B genes display reduced virulence are provided. In further aspects of the invention, flavivirus vaccine compositions such as West Nile virus vaccines are provided. In another embodiment the invention provides methods for vaccination against flavivirus infection.

La présente invention concerne des procédés et des compositions concernant des flavivirus mutants à virulence réduite. Dans certains modes de réalisation, l~invention concerne des séquences nucléotidiques qui codent des protéines flavivirales mutantes. L~invention concerne aussi des virus comprenant des gènes NS4B et NSI mutants affichant une virulence réduite. Dans d~autres aspects de l~invention, il est question de compositions de vaccin contre les flavivirus, tels que les vaccins contre le virus du Nil occidental. Dans un autre mode de réalisation, l'invention propose des procédés de vaccination contre les infections à flavivirus.

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