Attenuated strains of leishmania and uses thereof

Details Attenuated strains of leishmania and uses thereof Attenuated strains of leishmania and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 1/11 (2006.01) A61K 39/008 (2006.01) C12N 1/10 (2006.01) C12N 1/36 (2006.01) C12N 9/02 (2006.01)

Patent

CA 2204565

Attenuated strains of Leishmania are provided in which at least one gene contributing to virulence of the strain and expressed in both the promastigote and amastigote forms of the strain is functionally disabled, such as, by deleting at least a portion of the gene or by mutagenesis of the gene. The attenuated strain may be used for administration to a host to confer protection against disease caused by a virulent Leishmania strain or as a diagnostic reagent.

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