Attenuated vif dna immunization cassettes for genetic vaccines

Details Attenuated vif dna immunization cassettes for genetic vaccines Attenuated vif dna immunization cassettes for genetic vaccines

A - Human Necessities

61

K

A61K 38/00 (2006.01) A61K 39/12 (2006.01) A61K 39/21 (2006.01) A61K 39/38 (2006.01) A61K 39/395 (2006.01) A61K 39/40 (2006.01) A61K 39/42 (2006.01) C07H 21/02 (2006.01) C07H 21/04 (2006.01) C07K 1/00 (2006.01) C07K 14/16 (2006.01) C07K 16/00 (2006.01) C12N 7/04 (2006.01) C12P 21/06 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2304125

The present invention is directed to nucleic acid molecules encoding attenuated, non-functional virion infectivity factor (vif) proteins. The nucleic acid molecules of the invention are inserted into recombinant expression vectors and administered to mammals in order to induce a cellular and humoral immune response to the encoded protein product.

L'invention concerne des molécules d'acide nucléique codant des protéines du facteur d'infectiosité de virion vif non fonctionnel atténué. On insère ces molécules d'acide nucléique dans des vecteurs d'expression de recombinaison et on les administre à des mammifères, de manière à provoquer une réponse immune cellulaire et humorale à ce produit de protéines codées.

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