Attenuated viruses

Details Attenuated viruses Attenuated viruses

C - Chemistry, Metallurgy

12

N

C12N 15/43 (2006.01) A61K 39/13 (2006.01) C12N 7/04 (2006.01)

Patent

CA 2042318

ABSTRACT ATTENUATED VIRUSES An attenuated poliovirus in which the 5' non-coding region of the genome is: (a) the 5' non-coding region of poliovirus type 3 Leon strain modified by the provision of the bases uracil and adenine at positions 472 and 537 thereof respectively, or (b) the 5' non-coding region of another poliovirus modified by the provision of the bases uracil and adenine at respective positions corresponding to position 472 and 537 of the 5' non-coding region of poliovirus type 3 Leon strain.

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