C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/33 (2006.01) A61K 35/76 (2006.01) A61K 39/12 (2006.01) C07H 21/00 (2006.01) C12N 7/04 (2006.01) C12N 15/867 (2006.01) C12Q 1/68 (2006.01) C12Q 1/70 (2006.01)
Patent
CA 2201487
Disclosed are attenuated viruses, not naturally occurring, that contain one or more additional methylation sites in the genome of the virus compared to the corresponding wild-type virus. Preferably, the methylation sites are added into the genome of the virus by introducing an additional CG segment into the genome by means of a silent mutation. The attenuated viruses are useful for producing an immune response, including both the production of antibodies in animals for diagnostic use and the induction of protective immunity in a subject. Pharmaceutical formulations and methods of making the attenuated viruses are also disclosed.
On décrit des virus atténués, n'existant pas dans la nature, qui contiennent un ou plusieurs sites supplémentaires de méthylation dans leur génome par rapport au virus sauvage correspondant. Ces sites de méthylation sont de préférence ajoutés au génome du virus par l'introduction d'un segment CG supplémentaire dans ce génome au moyen d'une mutation silencieuse. Ces virus atténués servent à provoquer une réponse immunitaire employant tant la production d'anticorps chez des animaux à des fins diagnostiques, que l'introduction d'une immunité protectrice chez un sujet. On décrit aussi des formulations pharmaceutiques et des procédés qui permettent d'obtenir ces virus atténués.
East Carolina University
Gowling Lafleur Henderson Llp
LandOfFree
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