C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 7/01 (2006.01) A61K 39/12 (2006.01) A61K 39/13 (2006.01) A61P 31/12 (2006.01) A61P 37/04 (2006.01) C12N 15/09 (2006.01) C12N 15/86 (2006.01) C12N 7/04 (2006.01)
Patent
CA 2682089
This invention provides an attenuated virus which comprises a modified viral genome containing nucleotide substitutions engineered in multiple locations in the genome, wherein the substitutions introduce synonymous deoptimized codons into the genome. The instant attenuated virus may be used in a vaccine composition for inducing a protective immune response in a subject. The invention also provides a method of synthesizing the instant attenuated virus. Further, this invention further provides a method for preventing a subject from becoming afflicted with a virus-associated disease comprising administering to the subject a prophylactically effective dose of a vaccine composition comprising the instant attenuated virus.
L'invention concerne un virus atténué qui comprend un génome viral modifié contenant des substitutions de nucléotide conçues dans de multiples emplacements dans le génome, où les substitutions introduisent des codons désoptimisés synonymes dans le génome. Le virus atténué courant peut être utilisé dans une composition de vaccin pour induire une réponse immunitaire protectrice chez un sujet. L'invention propose également un procédé de synthétisation du virus atténué courant. En outre, la présente invention propose en outre un procédé permettant à un sujet de ne pas devenir affecté par une maladie associée à un virus comprenant l'administration au sujet d'une dose efficace d'un point de vue prophylactique d'une composition de vaccin comprenant le virus atténué courant.
Cello Jeronimo
Coleman John Robert
Futcher Bruce
Mueller Steffen
Papamichail Dimitris
Gowling Lafleur Henderson Llp
The Research Foundation Of State University Of New York
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