A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 51/00 (2006.01) A61K 31/409 (2006.01) A61K 31/555 (2006.01) A61K 41/00 (2006.01) A61N 5/00 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2474012
A method for the treatment of a tumor, comprising administering to a subject a therapeutically effectiveamount of a complex of a heavy element with a polydentate, pyrrole-containing macrocyclic ligandsubstituted with charged chemical groups, wherein said complex is capable of bringing said heavy elementinto close proximity to the nuclear DNA of cells in said tumor, and irradiating said tumor.
L'invention concerne un procédé pour le traitement d'une tumeur, consistant à administrer à un sujet une quantité efficace au niveau thérapeutique d'un complexe d'un élément lourd avec un ligand macrocyclique contenant du pyrrole, polydentelé et substitué avec des groupes chimiques chargés, ce complexe étant capable d'amener l'élément lourd très près de l'ADN nucléaire de cellules situées dans cette tumeur, puis à irradier cette tumeur.
Faraggi Moshe
Golan Yuval
Laster Brenda H.
Shani Gad
Ben-Gurion University Of The Negev Research And Development Auth
Kirby Eades Gale Baker
LandOfFree
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