Auristatin drug linker conjugates

Details Auristatin drug linker conjugates Auristatin drug linker conjugates

C - Chemistry, Metallurgy

07

K

C07K 7/02 (2006.01) A61K 38/07 (2006.01) A61K 39/00 (2006.01) A61K 47/48 (2006.01) C07K 19/00 (2006.01) G01N 33/567 (2006.01)

Patent

CA 2718942

Drug Linker compounds and Drug Linker Ligand conjugates are provided that have auristatins linked via the C-terminus. The conjugates show efficacy without the need for a self- immolative group to release the drug.

Cette invention concerne des composés lieurs de médicament et des conjugués lieur de médicament-ligand qui portent des auristatines liées via leur extrémité C-terminale. Les conjugués selon l'invention sont efficaces sans avoir besoin de recourir à un groupe dit « auto-immolable » pour libérer le médicament.

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