Auristatins having an aminobenzoic acid unit at the n terminus

Details Auristatins having an aminobenzoic acid unit at the n terminus Auristatins having an aminobenzoic acid unit at the n terminus

C - Chemistry, Metallurgy

07

K

C07K 14/47 (2006.01)

Patent

CA 2586909

Auristatin-type peptides are disclosed which are highly cytotoxic, synthetically accessible, and can be conjugated to antibodies and other ligands.

La présente invention a trait à des peptides de type auristatine qui sont hautement cytotoxiques, susceptibles d'être obtenus par synthèse, et qui peuvent être conjugués à des anticorps et d'autres ligands.

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