Autoantibodies utilized as carrier agents for pharmaceutical...

Details Autoantibodies utilized as carrier agents for pharmaceutical... Autoantibodies utilized as carrier agents for pharmaceutical...

A - Human Necessities

61

K

A61K 39/395 (2006.01)

Patent

CA 2551913

This invention describes a method whereby human autoimmune antibodies are used as carrier compounds to deliver imaging agents and pharmaceutical drugs to a tumor in the human patient. These autoantibodies have the propensity to localize in necrotic areas of tumors but not in healthy tissues. By combining various pharmaceutical agents with these carrier proteins it is possible to localize these agents within the necrotic areas of tumors in cancer patients. The carrier proteins may be combined with a variety of imaging agents for detection and diagnosis of tumors, and/or with a variety of radioactive or cytotoxic compounds for cancer treatment.

L'invention concerne une méthode dans laquelle sont utilisés des anticorps auto-immuns comme excipients pour l'injection d'agents d'imagerie et de médicaments pharmaceutiques sur une tumeur localisée dans le corps d'un patient. Ces autoanticorps ont tendance à être localisés dans les zones nécrotiques des tumeurs mais pas dans les tissus sains. La combinaison de divers agents pharmaceutiques avec ces protéines de transport permet de localiser ces agents dans les zones nécrotiques des tumeurs des patients cancéreux. Les protéines de transport peuvent être combinées avec divers agents d'imagerie pour la détection et le diagnostic de tumeurs, et/ou divers composés radioactifs ou cytotoxiques pour le traitement du cancer.

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