Autoinducer

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C - Chemistry, Metallurgy

12

N

C12N 1/38 (2006.01) C07D 207/24 (2006.01) C07D 211/72 (2006.01) C07D 307/33 (2006.01) C07D 309/30 (2006.01) C07D 333/30 (2006.01) C07D 335/02 (2006.01) C12N 15/67 (2006.01) C12Q 1/04 (2006.01)

Patent

CA 2105395

2105395 9218614 PCTABS00017 The compound N-(.beta.-ketocaproyl)L-homoserine lactone is shown to be an autoinducer that enhances gene expression in a wide variety of microorganisms. Use can be made of this property for diagnostic purposes, e.g. when gene expression causes bioluminescence or antibiotic production, or to promote bacterial growth. The invention claims use for these purposes of the compound and analogues of formula (1) where n is 2 or 3, each of X and Y is O, S or NH, and R is optionally-substituted C1-C12 alkyl or acyl. Some of these are also claimed as new compounds.

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