Autologous adoptive immunotherapy with primed...

Details Autologous adoptive immunotherapy with primed... Autologous adoptive immunotherapy with primed...

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61K 35/28 (2006.01) A61K 39/00 (2006.01) A61K 47/48 (2006.01) C12N 5/06 (2006.01)

Patent

CA 2376228

The invention relates to methods and compositions for promoting antigen- specific immune responses with an appropriate cytokine bias. More specifically, the present invention relates to methods of using autologous adoptive immunotherapy with antigen-specific, <i>ex vivo</i>-primed T cells or B cells to promote antigen-specific immune responses with a Th1 or Th2 cytokine bias.

La présente invention concerne des procédés et des compositions d'activation des réponses immunitaires spécifiques à l'antigène par sollicitation appropriée au moyen d'une cytokine. Plus spécifiquement, cette invention concerne des procédés d'utilisation d'immunothérapie adoptive autologue avec des cellules T ou des cellules B sensibilisées <i>ex vivo</i> spécifiques à l'antigène pour activer les réponses immunitaires spécifiques à l'antigène par sollicitation au moyen d'une cytokine Th1 ou Th2.

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