Autologous immune cell therapy: cell compositions, methods...

C - Chemistry – Metallurgy – 12 – N

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C12N 5/08 (2006.01) A61K 35/14 (2006.01) C12N 5/06 (2006.01) A61K 35/12 (2006.01)

Patent

CA 2227327

Compositions containing substantially homogeneous populations of functionally or phenotypically defined immune cells that have been isolated from a patient and expanded and/or differentiated ex vivo. Methods for treating or preventing disease or otherwise altering the immune status of the patient by reinfusing such cells into the donor are also provided. Methods for expanding and/or differentiating such cells ex vivo are also provided.

Compositions renfermant des populations essentiellement homogènes de cellules immunes définies par leur fonction ou leur phénotype, qui ont été isolées d'un patient puis développées et/ou différentiées ex vivo. L'invention porte également sur des méthodes de traitement ou de prévention d'une maladie ou de modification de l'état immunitaire du patient par réintroduction de telles cellules. L'invention porte enfin sur des méthodes de développement et/ou de différenciation de telles cellules ex vivo.

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