Autologous natural killer cells and lymphodepleting...

A - Human Necessities – 61 – K

Patent

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Details

A61K 35/14 (2006.01) C12N 5/06 (2006.01)

Patent

CA 2645042

The invention provides an isolated or purified T cell receptor (TCR) having antigenic specificity for a cancer antigen, e.g., a renal cell carcinoma antigen, wherein the TCR recognizes the cancer antigen in a major histocompatibility complex (MHC)-independent manner. Also provided are related polypeptides, proteins, nucleic acids, recombinant expression vectors, isolated host cells, populations of cells, antibodies, or antigen binding portions thereof, and pharmaceutical compositions. The invention further provides a method of detecting the presence of cancer in a host and a method of treating or preventing cancer in a host using the inventive TCRs or related materials.

La présente invention concerne un récepteur lymphocytaire T (TCR) purifié ou isolé ayant une spécificité antigénique pour un antigène tumoral, par ex., un antigène du cancer à cellules rénales, le TCR reconnaissant l'antigène tumoral indépendamment d'un complexe majeur d'histocompatibilité (MHC). La présente invention concerne également des polypeptides, des protéines, des acides nucléiques, des vecteurs d'expression recombinante, des cellules hôtes isolées, des populations de cellules, des anticorps ou des parties de liaison à l'antigène et des compositions pharmaceutiques. L'invention concerne en outre un procédé de détection de la présence d'un cancer chez un hôte et un procédé de traitement ou de prévention du cancer chez un hôte utilisant le TCR selon l'invention ou des matériaux s'y rapportant.

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