G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/68 (2006.01) G01N 33/50 (2006.01)
Patent
CA 2529590
The invention relates to an automatic method for the large-scale in vitro screening of cells, secreting at least one specific monoclonal antibody with affinity for a compound of interest, comprising: (10) distribution of antibody-producing cells on at least one culture plate, (12) culturing of said cells, (14) iterative screening of said cells for the secretion of antibodies with cloning of the cells secreting at least one antibody interacting with the compound of interest and (16) selection of at least one cell secreting a specific monoclonal antibody with affinity for said compound of interest.
La présente invention concerne un procédé automatisé de criblage in vitro et à grande échelle de cellules sécrétant au moins un anticorps monoclonal spécifique et affin pour un composé d'intérêt, comprenant (10) la distribution de cellules productrices d'anticorps sur au moins une plaque de culture ; (12) la culture desdites cellules ; (14) le criblage itératif desdites cellules pour la sécrétion d'anticorps, avec clonage des cellules sécrétant au moins un anticorps interagissant avec ledit composé d'intérêt ; et (16) la sélection d'au moins une cellule sécrétant un anticorps monoclonal spécifique et affin pour ledit composé d'intérêt.
Kadouche Jean
Lechuga Marc
Roseto Alberto
Monoclonal Antibodies Therapeutics
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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