Autotaxin variants and uses to treat diseases of metabolism

Details Autotaxin variants and uses to treat diseases of metabolism Autotaxin variants and uses to treat diseases of metabolism

C - Chemistry, Metallurgy

12

N

C12N 15/19 (2006.01) A61K 31/70 (2006.01) A61K 35/76 (2006.01) A61K 38/00 (2006.01) A61K 38/19 (2006.01) A61K 48/00 (2006.01) A61P 3/00 (2006.01) C07K 14/52 (2006.01) C07K 16/24 (2006.01) C12N 7/01 (2006.01) A61K 35/12 (2006.01)

Patent

CA 2372805

Alterations in insulin sensitivity are associated with diabetes, and conditions such as obesity and dyslipidemia. These diseases are complicated by elevated levels of circulating free fatty acid in the form of triglycerides, which is an important risk factor for the development of atherosclerosis. Diseases of metabolism such as obesity, dyslipidemia, and diabetes, can be treated by adminstration of pharmaceutical compositions that comprise either autotaxin polypeptides or their functional fragments, or nucleic acid molecules that encode autotaxin polypeptides or their functional fragments. Autotaxin polypeptides that are useful for such therapeutic methods are exemplified by new forms of human and rat autotaxin.

Les altérations de la sensibilité insulinique sont associées au diabète et à des troubles tels que l'obésité et la dyslipidémie. Des niveaux élevés d'acide gras en circulation libre sous forme de triglycérides, qui constituent une facteur de risque important pour l'athérosclérose, viennent compliquer ces troubles. Les troubles du métabolisme tels que l'obésité, la dyslipidémie et le diabète peuvent être traités au moyen de compositions pharmaceutiques renfermant soit des polypeptides d'autotaxine ou des fragments fonctionnels de ces derniers, soit des molécules d'acides nucléiques codant pour lesdits polypeptides ou leurs fragments. Les polypeptides d'autotaxine convenant pour de telles méthodes thérapeutiques renferment par exemples de nouvelles formes d'autotaxine de l'homme et du rat.

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