Avermectin-3,4-oxide derivatives useful as antiparasitic...

Details Avermectin-3,4-oxide derivatives useful as antiparasitic... Avermectin-3,4-oxide derivatives useful as antiparasitic...

C - Chemistry, Metallurgy

07

D

167/202, 260/233

C07D 493/22 (2006.01) A01N 43/90 (2006.01) A61K 31/70 (2006.01) C07H 19/01 (2006.01)

Patent

CA 2018102

15/DLR14 17694 TITLE OF THE INVENTION AVERMECTIN-3,4-OXIDE DERIVATIVES USEFUL AS ANTIPARASITIC AGENTS AND INSECTICIDES ABSTRACT OF THE DISCLOSURE There are disclosed avermectin derivatives in which the 3,4-double bond of the avermectins has been epoxidized. The compounds are prepared by oxidation of 7-0-trimethylsilyl-avermectins followed by deprotection. The compounds are active antiparasitic agents and insecticides and compositions for these uses are disclosed.

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