C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/52 (2006.01) C12N 1/21 (2006.01) C12N 9/00 (2006.01) C12N 9/88 (2006.01) C12P 19/62 (2006.01)
Patent
CA 2363714
An isolated DNA containing a DNA sequence encoding the avermectin aglycon synthase domain which is a multifunctional enzyme protein participating in the biosynthesis of polyketide compounds, or its variant having the avermectin aglycon synthase activity; in particular, a functional module and submodule in a sequence originating in Streptomyces avermitilis DNA; a polypeptide or its variant encoded by this DNA or its variant; a vector containing the DNA or its variant; a host cell transformed by the DNA, a modification thereof or the vector; and a process for producing avermectin.
Cette invention concerne un ADN isolé contenant une séquence ADN codant pour le domaine synthase avermectine aglycone, protéine enzymatique fonctionnelle qui participe à la biosynthèse de composés polyketide, ou de sa variante à activité synthase avermectine aglycone. L'invention concerne plus particulièrement un module et un sous-module prenant naissance dans de l'ADN Streptomyces avermitilis; un polypeptide ou une variante de ce polypeptide pour laquelle code cet ADN ou sa variante; un vecteur renfermant cet ADN ou sa variante; une cellule hôte transformée par l'ADN, une modification de celui-ci ou le vecteur. L'invention concerne également un procédé d'obtention d'avermectine.
Ikeda Haruo
Omura Satoshi
Fetherstonhaugh & Co.
The Kitasato Institute
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