C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 19/01 (2006.01) A01N 43/90 (2006.01) A61K 31/70 (2006.01) C07D 493/22 (2006.01)
Patent
CA 2080402
Avermectin analogs are disclosed wherein the 6,6-spiroketal ring system has been reduced in size to a 6,5-spiroketal ring system by the deletion of the 25-position carbon atom and the 25-alkyl substituent and which has a 23-acyl cycloalkyl, phenyl or substituted hydroxymethyl substituent. This is accomplished by opening the outer spiroketal ring with the elimination of ring carbon atoms 23, 24 and 25 and the alkyl substituent at the 25-position and incorporation a new component, reclosing the spiroketal to a 5-membered ring with a 23-acyl substituent and new substituents at the 24-position. The compounds are used as anti-parasitic insecticidal and anti-helmintic agents in humans and animals and compositions containing such compounds as the active ingredient thereof are also disclosed.
Meinke Peter T.
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
LandOfFree
Avermectin compounds with a 6,5-spiroketal ring system and a... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Avermectin compounds with a 6,5-spiroketal ring system and a..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Avermectin compounds with a 6,5-spiroketal ring system and a... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1662076