Avermectin derivatives

Details Avermectin derivatives Avermectin derivatives

C - Chemistry, Metallurgy

07

H

260/210, 260/228

C07H 17/08 (2006.01) A61K 31/70 (2006.01) C07H 19/01 (2006.01) C07H 23/00 (2006.01)

Patent

CA 2008150

01/DLRl2 -1- 17848 TITLE OF THE INVENTION AVERMECTIN DERIVATIVES BACKGROUND OF THE INVENTION The term avermectin (previously referred to as C-076) is used to describe a series of compounds isolated from the fermentation broth of an avermectin producing strain of Streptomyces avermitilis and derivatives thereof. The morphological characteristics of the culture are completely described in U.S. Patent No. 4,310,519. The avermectin compounds are a series of macrolides, each of which is substituted at the 13 position with a 4-(.alpha.-L-oleandrosyl)-.alpha.-L-oleandrose group. The avermectin compounds and the instant derivatives thereof have a very high degree of anthelmintic and anti-parasitic activity.

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