Avermectin derivatives with a spacer inserted between the...

Details Avermectin derivatives with a spacer inserted between the... Avermectin derivatives with a spacer inserted between the...

C - Chemistry, Metallurgy

07

D

C07D 493/20 (2006.01) A01N 43/90 (2006.01) A61K 31/70 (2006.01) C07H 15/26 (2006.01) C07H 19/01 (2006.01)

Patent

CA 2042418

TITLE OF THE INVENTION AVERMECTIN DERIVATIVES WITH A SPACER INSERTED BETWEEN THE DISACCHARIDE AND THE AGLYCONE USEFUL AS ANTIPARASITIC AGENTS ABSTRACT OF THE DISCLOSURE There are disclosed avermectin derivatives which incorporate a spacer between the disaccharide and the aglycone. The synthetic spacer-containing analogs are derived from the corresponding aglycones which in turn are prepared by chemical modification of naturally occurring avermectins. The compounds are active antiparasitic agents and compositions for that use are disclosed.

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