Avermectin ketal derivatives useful as antiparasitic agents

Details Avermectin ketal derivatives useful as antiparasitic agents Avermectin ketal derivatives useful as antiparasitic agents

C - Chemistry, Metallurgy

07

H

167/202, 260/227

C07H 17/08 (2006.01) A01N 43/90 (2006.01) A61K 31/70 (2006.01) C07D 493/22 (2006.01)

Patent

CA 2010078

8/DLR14 17874 TITLE OF THE INVENTION AVERMECTIN KETAL DERIVATIVES USEFUL AS ANTIPARASITIC AGENTS ABSTRACT OF THE DISCLOSURE There are disclosed avermectin aglycone derivatives which incorporate a ketal at position 13. The synthetic ketal analogs are derived from the corresponding ketones which in turn are prepared by chemical modification of naturally occurring avermectins. The compounds are active antiparasitic agents and compositions for that use are disclosed.

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