G - Physics – 01 – N
Patent
G - Physics
01
N
167/37
G01N 33/577 (2006.01) G01N 33/53 (2006.01) G01N 33/543 (2006.01)
Patent
CA 2035162
ABSTRACT The present invention enables the performance of immunoassays which use mouse monoclonal antibody assay reagents but in which human anti-mouse antibody-induced interference is substantially avoided without the need for cumbersome sample pretreatment steps and without denaturing the analyte epitope(s) necessary to the binding reactions of the immunoassay. The present invention also enables the determination of the presence or amount of interfering antibodies in the test sample. For example, bridging assays for the detection of the presence or amount of human anti-mouse antibodies in a test sample can be configured to determine anti-allotype, anti-idiotype antibodies and/or anti- isotype antibodies. Homogeneous and heterogenous assay methods and sandwich and competitive assay formats are described.
Daufeldt Judith A.
Hass G. Michael
Henslee Jerry G.
Kinders Robert J.
Ostrow David H.
Abbott Laboratories
Daufeldt Judith A.
Goudreau Gage Dubuc
Hass G. Michael
Henslee Jerry G.
LandOfFree
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